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IHME data shows that the United States, Canada, Australia, New Zealand, Japan, South Korea, and countries in Western Europe experienced steep declines over the past two decades that have begun to taper off and plateau

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Amongst 1,053 people without frequent exacerbations , SUNSET (2018) compared continued triple therapy for up to 26 weeks (tiotropium 18 mcg/d + salmeterol 50 mcg / fluticasone 500 mcg twice/d) with abrupt discontinuation of ICS after long-term triple therapy , replaced by once daily LAMA/LABA (indacaterol 110 mcg / glycopyrronium 50 mcg)

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Young adults also were more likely to use both e-cigarettes and combustible cigarettes compared with adults 45 and older

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