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This suggests that, compared to the requirement for GSH synthesis in embryonic development 14,15,16 , GSH synthesis is dispensable to several organs in adult animals

Likewise, the histomorphometric image analysis of H and E-stained tissue sections was constant with FPN-induced neurotoxicity

The subsequent conversion of PCA to 5-methyl phenazine-1-carboxylic acid betaine (MPCBA) requires an additional gene, phzM , which encodes the enzyme phzM, an S-adenosylmethionine (SAM) dependent phenazine-specific methyltransferase that catalyzes the attachment of a methyl group to the nitrogen-phenazine group of PCA

In degenerative chondrocytes, elevated IL-6 expression triggers lipid peroxidation and iron imbalance via the IL-6/miR-10a-5p/IL-6R axis, thereby promoting ferroptosis and exacerbating inflammation associated with intervertebral disc degeneration (Jeong et al., 2003)

Utility of antioxidants in the treatment of male infertility: clinical guidelines based on a systematic review and analysis of evidence

doi: 10.1016/j.ijwd.2015.02.001 201 BoweWPFilipJCDiRienzoJMVolginaAMargolisDJ