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For antiretroviral drugs, several observational studies have been conducted or are ongoing, focusing on birth outcomes, with some studies extending analysis to early development, which have provided critical data on rates of vertical transmission, maternal health, and neurodevelopmental effects of various ART regimens during pregnancy (Gibb et al., 2012

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Given that GSSG was significantly accumulated in the A2ARi-treated activated CD8 + T cells (Figure 3H), we hypothesized that the T cell ferroptosis induced by A2ARi could be due to the enhanced GSH usage and subsequent increased GSSG accumulation