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This state, characterized by an imbalance between ROS production and elimination by the antioxidant system in favor of ROS formation, is termed oxidative stress (Sies 2023)

Stay at the current dose for an additional 4 weeks (or longer) until symptoms subside

10.1371/journal.pone.0157855 89 JonesS

Furthermore, it promotes the polarization of microglia from the pro-inflammatory M1 phenotype (indicated by a decrease in the CD86 + ratio) to the anti-inflammatory M2 phenotype (indicated by an increase in the CD206 + ratio)