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[Google Scholar] Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL

The mRNA levels of genes of interest were normalized using a eukaryotic 18S rRNA endogenous gene expression control (FAM-MGB probe, non-prime limited

This was because the drug did not significantly reduce weight in 536 subjects over the course of 24 weeks 2

Specifically, canagliflozin exerts its protective effect on the kidneys by regulating the SIRT3/FoxO3a/catalase pathway to reduce oxidative stress, inhibiting EMT in the HSD-induced dahl salt-sensitive rat hypertensive renal injury model and Ang II-treated HK-2 cells