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[14] Insufficiency [edit] In pernicious anemia, which is usually an autoimmune disease, autoantibodies directed against intrinsic factor or parietal cells themselves lead to an intrinsic factor deficiency, malabsorption of vitamin B 12 , and subsequent megaloblastic anemia

Weight loss through lifestyle changes costs less but doesn't address stubborn pockets that resist diet and exercise

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ABOUT B12 Vitamin B12 plays a key role in how your body produces energy, supports your nervous system, and converts food into fuel

The macrocycle spans residues AspLys via a side-chain lactam, producing a conformationally constrained ring that distinguishes it structurally from linear -MSH precursors