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Even if cysteine S -conjugate -lyase is responsible for the synthesis of the highly reactive and cytotoxic thiol version of cisplatin ( Figure 1 ), the activation of cisplatin into a nephrotoxin relies on the three previous steps of the classical mercapturic acid pathway involving GSTs (GSH conjugation), GT (production of CisPt-cys-glu) and dipeptidase (production of CisPt-cys

11:e0005118

Int J Mol Sci (2020) 21:3743

Advanced ovarian cancer is often accompanied by ascites, excessive fluid accumulation in the abdominal cavity 23 , and routine medical care involves ascites drainage

Provides long-lasting hydration 4

In addition, predictive biomarkers could be identified for disease states such as obesity, IBD and cancer that are characterized by alterations in the GI tract microbiota 45