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293 NQO1, an enzyme involved in the elimination of ROS, is inhibited by HBx, leading to decreased GSH levels and increased susceptibility of hepatoma cells to oxidative damage, cumulating in HBV-associated pathogenesis of chronic liver diseases

Although it serves as an essential cofactor for critical enzymes governing antioxidant defense, energy production, and structural integrity, its dysregulationmanifesting as either deficiency or excessis a common pathogenic thread across diverse cardiovascular conditions