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Description

K-Hcy, rather than acetylation, drives cytoplasmic translocation and extracellular release of high mobility group box proteins 1 and 2 (HMGB1/2), amplifying the senescence-associated secretory phenotype (SASP)

PRO1184 exerted potent cytotoxic activity in murine xenograft models across a range of FR expression levels, consistent with on-target potency as well as bystander activity

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