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The two-pathway strains W303-1b/FG and W303-1b/FP were obtained by the integration of linearized pGAPh-gsh2gsh1 and pGAPg-pro1gshB, respectively

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Therefore, there is an urgent need to develop antioxidants with high renal accumulation and effective renal clearance to deplete RONS in the kidney [153, 155, 156]

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Inhibition of Notch3 or treatment with DAPT (a selective inhibitor of -secretase) in experimental models of hypoxia-PH attenuates these effects, highlighting the contribution of Notch-CaSR signaling to PH development

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These results may imply that surplus l-Ser production or decrease of 3PG by enhanced l-Ser biosynthesis exerts unfavorable effects on growth and glutathione production of host cells

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