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Guttenplan KA, Weigel MK, Prakash P, Wijewardhane PR, Hasel P, Rufen-Blanchette U, et al

N Engl J Med 317:687694

Acknowledgements This review was supported by the National Natural Science Foundation of China (32161143021, 81271410), the Henan University graduate Talent Program of Henan Province (SYLYC2023092), and the Henan Natural Science Foundation of China (182300410313)

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Determining the future potential for tirzepatide in CRM disease will depend on the outcomes of dedicated CV and kidney trials, but it is tempting to consider whether it might provide a treatment option for individuals at risk (Fig