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This is the central scientific question, and the answer is: possibly in some experimental systems, but the evidence base is still narrow

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Gastroenterology 112 :855863

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AAV2-based vectors have been used in clinical trials to deliver therapeutic genes to the striatum or SNpc, showing safety and moderate benefit (Niethammer et al., 2017

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As this pathway is VEGF independent, it can maintain angiogenesis in presence of anti VEGF pathways drugs

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Clinical Pediatrics, 54(1), 1924

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GADD45 deficiency decreased the activity of the SIRT1 target AMPK, resulting in lipogenesis exacerbation

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