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Activation of these receptors triggers two complementary processes: it accelerates lipolysis (the breakdown of stored triglycerides into free fatty acids for energy) while simultaneously inhibiting lipogenesis (the conversion of glucose and other substrates into new fat stores)

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Without intrinsic factor, B12 cannot cross the gut wall, and red blood cell production, nerve maintenance, and DNA synthesis all suffer

They may also have subclinical conditions that could be affected by metabolic changes

It is to say that the safety conversation does not produce specific red flags from the combination itself