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Stein et al., 2015)

Although some clinical trials are in progress, due to severe side effects such as those caused by an undesired pharmacological activity, suppression of the innate immune response to viral and bacterial infections, and damage to the central nervous system and liver, 244,245 these drugs remain challenging for a clinical application

Pharmacodynamic studies comparing administration routes showed that oral delivery of crocodilian oil reached peak anti-inflammatory activity at 3 h (60.8% 5.5%), whereas topical application peaked at 12 h (57.9% 5.9%) (14)

Biallelic variations in SDHB frequently result in complex II deficiency