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Despite, or due to, the lack of clinical improvement after previous therapies, all patients were very keen to explore other treatments

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Research history of metal ions in neurodegenerative diseases As early as 1924, iron deposition was first observed in the globus pallidus (GP) of PD patients through Perls and Turnbull staining (Fig

Periodontal EDS (pEDS) is characterized by severe and intractable periodontitis of early onset (childhood or adolescence), lack of attached gingiva, pretibial plaques, and family history of a first-degree relative who meets clinical criteria Cardiac-valvular EDS (cvEDS) is characterized by severe progressive cardiac-valvular problems (aortic valve, mitral valve), skin problems (hyperextensibility, atrophic scars, thin skin, easy bruising), and joint hypermobility (generalized or restricted to small joints)

For example, BNIP3 expression is induced by HIF-1 under hypoxia and by FOXO3 during nutrient stress, linking mitophagy activity to cellular metabolic and stress transcriptional programs