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However, the metabolic response fueling the molecular mechanisms underlying changes in innate immune cell homeostasis remain undefined

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Finally, FGF21 reduces expression and activation of the NLRP3 inflammasome in vascular endothelial cells in diabetic mice (184), which both protects the cells themselves and reduces further inflammatory damage by suppressing pyroptosis and immune cell recruitment (185)

Lenti MV, et al

I honestly did not know about the decaffeination process until about 5 years ago so I am guessing that a lot of other people may not know about it either