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Pharmacologic successes have unfortunately not kept pace with the increasing pathophysiologic insights into ALS, leading to only a few medications approved for use globally, none of which stop or reverse disease progression

This cell-membrane protein, which occurs in high amounts on cancer cells, pumps chemotherapeutic agents out of cancer cells

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These differences need to be taken into consideration when choosing cell lines for studies of ROS-inducing processes and for the interpretation of the results

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