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The dual agonist action (GIP and GLP-1 receptors) does not directly suppress thyroid function, but the metabolic shift from weight loss requires TSH monitoring every 68 weeks during the initial phase

There are excellent reviews and clinical guidelines addressing the management of APL.69 In Brazil, the last published recommendations on APL management date from 2013, when the association of ATRA and ATO was not a current practice.10 Therefore, the creation of a Brazilian consensus is particularly needed because: 1) APL is a peculiar subtype of AML that requires specific treatment

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The results indicated an absence of discernible pathological differences in the histological morphology of all examined organs when compared to the PBS control group ( Figure S27a )