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While the liver was the focus, hypoxia systemically impacts multiple organs through oxidative mechanisms

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Mitochondrial respiratory chain complex 1 is targeted by metformin and its inhibition is involved in AMP-activated protein kinase-independent regulation of hepatic gluconeogenesis by triggering alterations in cellular energy charge and redox state

The potential of fenofibrate for diabetic neuropathy has also been explored in humans using surrogate measures of nerve health, namely corneal nerve fiber density (CNFD) using in vivo confocal microscopy

PMID: 15403077