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They die in an orderly, programmed fashion rather than through necrosis, which would cause inflammation

The TME is hypoxic, and both hypoxia and high lactate concentrations may be key drivers of the recruitment and polarization of tumor-associated macrophages (TAMs) 147

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Andersson M, BjrkhemBergman L, Ekstrm L, Bergqvist L, Lagercrantz H, Rane A, et al

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This acetyl shield effectively hides the vulnerable peptide bonds from the destructive digestive enzymes in the gut, allowing the entire molecule to survive the gastrointestinal tract and pass seamlessly through the intestinal wall into the bloodstream