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Moreover, the upregulation of HK2 in the liver confers protection against liver IR injury mediated by RIPK1 kinase, while depleting HK2 in HCC cells enhances TNF-induced cell death and synergistically improves the efficacy of anti-PD1 therapy in an HCC model

Invasion of a tumor is increased by MMP-2 and MMP-9, which destroy the extracellular matrix, allowing metastatic cancer cells to enter the bloodstream [205]