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Chronic demyelination in MS results either from an age-related decline in oligodendrocyte precursor cells (OPCs) or a reduced ability of these cells to differentiate into mature oligodendrocytes (mOL) in the environment of the WM lesions due to the presence of pro-inflammatory cytokines and myelin inhibitory proteins (57, 58)

10.1016/j.ejphar.2023.175782 117 WangY.LanX.LiuN.MaL.DUJ.WeiW.et al (2024b)

[PubMed] 61.Chen JY, Chu CC, So EC, Hsing CH, Hu ML

doi: 10.1073/pnas.1501305112, 57

doi: 10.3892/mmr.2020.11114 126 WenL.ShiD.ZhouT.TuJ.HeM.JiangY.et al

In 681 asthma patients, the wild-type allele had a prevalence of 81.7%, with the alleles of three, four, and six motifs having prevalence rates of 14.7%, 3.3%, and 0.3% respectively