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When managing patients taking opioid analgesics, particularly those who have been treated for an extended period of time and/or with high doses for chronic pain, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper

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VulliamyTJDUrsoMBattistuzziGEstradaMFoulkesNSMartiniGet alDiverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia

The thiol-disulfide equilibrium within the cell is known to regulate a diverse number of metabolic processes including enzyme activity, transport activity, signal transduction, and gene expression via alteration of redox sensitive transcription factors such as activator protein-1 (AP-1), nuclear factor kappa B (NFB) and p53 (Hutter et al., 1997

Preclinical models converge on immuneinflammatory signaling, HPA axis dysregulation and neurotransmitter alterations as recurrent mechanistic pathways (Ravi et al., 2021