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TSTA3 overexpression promotes malignant characteristics in LUSC by regulating LAMP2-mediated autophagy and tumor microenvironment

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In the in vitro study, the concentration of lutein needed to inhibit phase I enzymes 50% was less than 12 mg/mL for CYP1A1, CYP1A2, CYP2B1/2, aniline hydroxylase, and aminopyrine- N -demethylase

mRNA 3-UTR shortening is a molecular signature of mTORC1 activation

Furthermore, in transgenic mouse models expressing human -syn, hepatic -syn protein levels exhibit time-dependent accumulation despite the absence of -syn mRNA expression in the liver under neuron-specific promoter regulation, suggesting a potential neural system-derived origin of the protein [57]

These changes typically come as a cluster, not in isolation