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Therefore, its contribution to RGC damage and optic nerve degeneration should not be overlooked [322]

The details of mouse strains used in each experiment are described in Table S3

Mechanistically, dietary MR was found to downregulate proprotein convertase subtilisin/kexin type 9 (PCSK9), a negative regulator of MHC-I expression and TCR signaling, through inhibition of DNA methylation (116)

S., Estvez A

Nevertheless, sulphasalazine has been demonstrated to be an effective treatment in cancer models, by inhibiting xCT to activate ferroptosis 232,233 and restore sensitivity to chemotherapy