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Dosage: While dosage primarily affects the peak concentration (Cmax) and total exposure (AUC), it can sometimes indirectly influence apparent half-life in a non-linear fashion, especially if metabolic pathways become saturated

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Intracellular H 2 O 2 (hydrogen peroxide) and ROS levels increased with NiO-NP doses, as did electrolytic leakage from damaged cells

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In the adipose tissue of insulin-resistant and obese patients, treatment with selenite was shown to enhance insulin receptor expression in 3T3-L1 pre-adipocytes, improving adipocyte differentiation and function through the induction of GPX3 expression and activation of the transcription factor SP1 [26]