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In contrast, active monomers isolated from TCMs have clear pharmacological mechanisms and specific molecular targets

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Compounds 3a and 3b have been reported in the literature, while the 3c series remains undocumented ( 3 catalysis, PCl 3 is activated by Lewis acid to form the electrophile [Cl 3 P + ] which attacks the benzene ring, proceeding through a -complex intermediate

This protocol caused severe intestinal inflammation in mice, leading to weight loss, diarrhea, and rectal bleeding, as is characteristic of DSS colitis

Activating Transcription Factor 3 in Cardiovascular Diseases: a Potential Therapeutic Target

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