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TCA cycle intermediates were undetectable when [ 15 N, 13 C 5 ]valine was used as substrate, likely reflecting the low intrinsic levels of BCAT in the human liver and the further decrease in expression of metabolic genes (including BCAT) known to occur upon plating of hepatocytes

They must comply with Current Good Manufacturing Practices (cGMP) similar to traditional pharmaceutical manufacturers

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Neurochem Int 61:100107 Soetekouw PM, Wevers RA, Vreken P, Elving LD, Janssen AJ, van der Veen Y, Bleijenberg G, van der Meer JW (2000) Normal carnitine levels in patients with chronic fatigue syndrome

and Ewbank, J.J

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