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Dani, I

Associated with migraines (headaches and abdominal)

The optimal retatrutide dose in any research context depends on the balance between efficacy and tolerability

External general factors related to stress, climate, or living environment (urban/rural)

Abbreviations AA Arachidonic acid (20:4n-6) ALA Alpha-linolenic acid (18:3n-3) BA 10 Brodmann area 10 CNS Central nervous system cPLA2 A calcium-dependent AA-specific cytosolic PLA2 CSF Cerebrospinal fluid DA Dopamine (3,4-dihydroxyphenethylamine) DHA Docosahexaenoic acid (22:6n-3) DPA Docosapentaenoic acid (22:5n-3) EPA Eicosapentaenoic acid (20:5n-3) FABP Fatty acid binding protein FAD Fatty acid desaturase GM Grey matter GPCR G-protein-coupled receptor GSH Glutathione 5-HT Serotonin (5-hydroxytryptamine) iPLA2 A calcium-independent DHA-specific PLA2 KYNA Kynurenic acid LA Linoleic acid (18:2n-6) NMDAR N-methyl-D-aspartate receptor PANSS Positive and negative symptom scale PFC Prefrontal cortex PLA2 Phospholipase A2 PUFA Polyunsaturated fatty acid PGE2 Prostaglandin E2 RBC Red blood cells RCT Randomized-controlled trial sPLA2 A calcium-dependent AA-specific secretory PLA2 SOD Superoxide dismutase TAC Total antioxidant capacity UHR Ultra-high risk VTA Ventral tegmental area WM White matter Authors contributions The author (MCH, YSH, WCO) contributed to the study conception and design, and writing of the manuscript

Korkmaz A, Kaymak SU, Neeliolu S, Erel