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A 2000 study involving obese Zucker rats concluded that Fragment 176-191 did not negatively impact insulin sensitivity [11], while a 2001 study involving obese mice found that insulin secretion was unaffected [12]

Using NADPH as an electron donor, it breaks the disulfide bond of GSSG and reduces it to two GSH molecules, thereby maintaining a high GSH/GSSG ratio within the cell

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Mol Cell Biochem 39:357368 Thon VJ, Vigneron-Lesens C, Marianne-Pepin T, Montreuil J, Decq A, Rachez C, Ball SG, Cannon JF (1992) Coordinate regulation of glycogen metabolism in the yeast Saccharomyces cerevisiae