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Symptoms manifest as motor disorders on the contralateral side of the injection site, facilitating the observation of clinical intervention effects, with minimal unrelated side effects and a high survival rate (Schober, 2004)

In a clinical trial of secukinumab in 59 patients with severe CD, IL-17inhibitors were not only ineffective, but also associated with adverse events and CD deterioration [14]

Importantly, this hypothesis must be distinguished from ongoing inflammation, small-fiber neuropathy, and residual immune-mediated tissue damage (197200)

doi: 10.3390/MOLECULES25225243 293 SafeSJayaramanAChapkinRSHowardMMohankumarKShresthaR

2008;268:1725 [cited 2020 mar 12] Available from: Shimomoto T, Collins LB, Yi X, Holley DW, Zhang Z, Tian X, et al

& Arnsten, A