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For example, studies suggest that ashwagandha can help treat hypothyroidism (low levels of certain thyroid hormones).16 That has led some researchers to fear that it may be dangerous for anyone on thyroid medications or those with even mild hyperthyroidism

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J Med Chem 43:527550 Stopponi S, Somaini L, Cippitelli A, Cannella N, Braconi S, Kallupi M, Ruggeri B, Heilig M, Demopulos G, Gaitanaris G (2011) Activation of nuclear PPAR receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking