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It enhances insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system effects

Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor

More frequent smaller doses are often better at achieving actual steady levels

This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted

It has not been approved by the U.S

It's commonly used by athletes recovering from soft tissue injuries like rotator cuff strains, ACL/MCL tears, and elbow or knee tendonitis