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In both THP-1-derived macrophages and primary human bone marrow-derived macrophages, both Osimertinib and CP-24 significantly upregulated the transcription of M1 marker genes, including CD68, CD88, CD80, ITGAX, and CXCL16, while exerting minimal effects on the transcription level of M2 marker genes such as TGFB1 (Fig

doi:10.1038/s41422-023-00844-w 54

the C-terminal protein cleavage comprises inducing a thio-induced C-terminal cleavage

Wang X, Sirianni A, Pei Z, et al

doi: 10.3390/biomedicines11102791 244 ElbandrawyAMYousefAMMorganENEwaisNFEidMMElkholiSMet al

However, when 2,6-chloroindophenol (DCPIP) was used as artificial electron acceptor both native LhgO in the membrane fraction and recombinant LhgO revealed higher activities in the presence of ubiquinone 1 compared to menaquinone 4 (Fig