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Homocysteine and its relationship to cardiovascular disease emerged in the late 1960s, when Kilmer McCully, MD encountered two children with homocystinuria (a rare autosomal recessive condition) who had advanced atherosclerosis, although the coronary plaques contained no lipids

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SAM, SAH, methionine and homocysteine A plasma methylation panel gives more direct information about methyl supply, methylation inhibition and methionine-cycle dynamics

Once reconstituted with a sterile laboratory solvent, store at 28C and avoid repeated freeze/thaw cycles to maintain compound integrity

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