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Black cumin seedlings pretreated with KAR effectively countered salinity-induced effects by lowering ROS levels and boosting the activities of enzymes involved in the ascorbate glutathione cycle, along with other antioxidants like CAT, POX, and SOD, as well as osmoprotectants such as proline (Sharifi and Shirani Bidabadi, 2020)

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BMSC-derived exosomes alleviate sepsis-associated acute respiratory distress syndrome by activating the Nrf2 pathway to reverse mitochondrial dysfunction

Supports healthy immune function, detoxification, protects cells from damage cause by free radicals, peroxides, and heavy metals, and improves metabolic energy

This causes dissipation of the internal membrane potential and generation of ROS, followed by rupture of the external membrane and non-specific release of intermembrane space proteins into the cytosol, which activate various signal transduction pathways such as apoptosis (84)