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A novel class of oral, non-immunosuppressive, beta cell-targeting, TXNIP-inhibiting T1D drugs is emerging

Copper-dependent generation of Cu + and ROS within mitochondria rapidly blocks Fe-S assembly, disabling TCA cycle enzymes and precipitating cuproptosis while simultaneously derepressing IRP2 to raise labile iron, thereby amplifying lipid peroxidation and ferroptotic death (Lin et al

doi: 10.3390/ijms23073938 [DOI] [PMC free article] [PubMed] [Google Scholar] 41

Journal of Cosmetic Dermatology, 9(3), 191198

A systematic evaluation of peripheral cytokines (e.g., via multiplex Luminex assays) will be conducted in follow-up studies to map gut-derived immune signals to CNS pathology

[1] Duffy SL et al