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To view a copy of this licence, visit About this article Cite this article Chen, Y., Wu, G., Zhang, W

doi: 10.1016/j.ccr.2009.12.020 47 XuCHouPLiXXiaoMZhangZLiZet al

2.2 Cellular injury and necrosis during ischemia: a pathophysiological cascade The decline in blood flow during ischemia triggers a cascade of biological events that ultimately lead to cell death