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Green DR, Galluzzi L, Kroemer G

Additionally, another metabolite, E3, produced through 16-hydroxylation, has been found to strongly stimulate the expression of tumor necrosis factor (TNF) and IL-6, implying its potential proinflammatory role in PH [65]

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All participants were non-smokers, engaged only in light physical activity and neither had previous pituitary disease (including known GH deficiency) or surgery nor received GH replacement