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Similar to the mechanism GSTs use for catalyzation of redox reactions, the mechanism for detoxification first involves the binding of two substrates to the enzyme

The death receptor pathway is initiated when death ligands, such as TNF and Fas ligand, bind to their respective receptors, activating caspase-8 and downstream effector caspases, ultimately leading to apoptosis (77)

Food and Drug Administration (FDA) has approved various small-molecule drugs for cancer chemotherapy, including doxorubicin (DOX), camptothecin (CPT) and its derivative SN-38, gemcitabine (GEM), paclitaxel (PTX), 5-fluorodeoxyuridine (FDU), cisplatin, carboplatin, and oxaliplatin (Figure 1) (Liu et al., 2023

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10.1007/s11427-010-0036-1 168 YaoM.LiJ.ZhangJ.MaS.WangL.GaoF.et al (2021)

i , Quantification of cells with TDP-43 aggregates after HS and recovery as in h ( n = 4 fields, 131 and 161 cells were analysed for sgCtrl and sgPML, respectively)