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ATOX1 transports Cu to the nucleus, where it binds to transcription factors and drives gene expression

Zhou L, Gao Q, Nie M, Gu JL, Hao W, Wang L, et al

Mitochondrial oxidative stress, mitochondrial ROS storms in long COVID pathogenesis

Elevated circulating concentrations of APAP-protein adducts are seen in mice and man

And antagonism of CYP2E1 is easily achieved with 10 or 15 mg/kg fomepizole, doses used for treatment of toxic alcohol poisoning and as demonstrated in Kangs study on APAP metabolism