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ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ERmitochondria contact sites

The timing of your treatment affects the outcome

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They also show toxic effects on mitochondrial DNA, which is sensitive to such compounds

692,693 Mutations in key TCA cycle enzymes, such as SDH, fumarate hydratase, and IDH, lead to TCA cycle dysfunction and mitochondrial metabolic defects across various human cancers