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Two patients showed low levels of pre-existing antibodies to uricase at baseline

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Particularly, the highly reactive 4-OH group on the catechol moiety was selectively blocked by DNBS

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DOPA decarboxylase converts DOPA to dopamine, dopamine -hydroxylase converts dopamine to norepinephrine, and phenylethanolamine N -methyltransferase converts norepinephrine to epinephrine

In research models, these peptides stimulate growth hormone (GH) release by activating the ghrelin/GHS-R receptor