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The blocking of neurotransmitters' transportation to their vesicles increases their concentration in the cytosol and this in turn exposes them to oxidative deamination by monoamine oxidase (MAO), the enzyme found in the mitochondrial outer membrane

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Enzyme-mediated lysine lactylation The precise execution of enzyme-mediated lactylation requires the assistance of specialized tools

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All patients experienced reductions in pruritus from Baseline regardless of VLX dose with intermittent relief coinciding with resumption of dosing where doses were interrupted