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Some miRNAs have been shown to modulate ferroptosis

The ubiquitination of BAK at lys113 impairs its activation, oligomerization and apoptotic activity [29]

Similar findings were made by Hagi et al

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Its often asymptomatic progression leads to nearly half of cases being diagnosed at advanced stages, limiting therapeutic efficacy ( To systematize cancer complexity, the hallmarks framework was established and later expanded to encompass 14 capabilities acquired during tumorigenesis, defining core functions that drive malignant progression and guide therapeutic targeting ( Under physiological conditions, L-arginine homeostasis is tightly controlled through a coordinated network of extracellular transport, intracellular synthesis, and enzymatic conversion