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Additionally, the metabolism of arginine influences macrophage polarisation, with M1 macrophages producing toxic nitric oxide (NO) and M2 macrophages contributing to tissue repair and healing through the arginase pathway (60, 61)

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Each subgroup is then analyzed in relation to the other using the volume (Criteria 1 and 2), average cost (Criteria 3 and 4), and reduction in variance (Criteria 5)

As expected, most of the irradiated cells, except NCI-H1975 and Calu-6, showed an increase in residual DNA damage 24 h post-RT, which was not further enhanced by the combination treatment (Supplementary Fig