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Hepatocellular Carcinoma in NASH: Is there a biological Rationale

( b ) Immunoblot of TMLHE

To further explore the relationship between ferroptosis and fibrotic factors in HK-2 cells, we established a GPX4-overexpressing plasmid system in HK-2 cells and treated the cells with TGF- for 48 h (Fig

Furthermore, AMPK, inhibits SLC7A11 activity and GSH synthesis through mediating phosphorylated BECN1, further facilitates ferroptosis in cancer cells (Chen et al, 2021)

Ebselen ameliorates renal ischemia-reperfusion injury via enhancing autophagy in rats

465,466,467 Moreover, addiction build-up seems to be linked to astrocytic NMDA receptors, such that deletion of the NR2C subunit specifically from astrocytes potentiated extinction of cocaine preference memory