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Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer

It should also be noted that ROS generates a metabolic syndrome due to changes in energy metabolism, activation of RNS, xanthine oxidase, increased expression of inflammatory mediators, and low levels of GPx and other antioxidant enzymes

Funding The work was sponsored by the National Natural Science Foundation of China (31802208) and the Science and Technology Research Project of Education Department of Hubei Province (Q20221302)