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As expected, even after the initial saturation of SemD Rhod with one of the binding partners, the second partner was immediately recruited by SemD Rhod (Fig

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Patients were randomized to follow a therapeutic cycle for a total period of eight years: citicoline (1,000 mg/day, by intramuscular injection) or placebo (-blockers alone) for a two-month period followed by a four-month washout period (87)

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Pyruvate, -ketoglutarate, glutamate, and aspartate all stayed constant between the two groups (Figure 1)