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A subsequent study identified the compound N-(4-(2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)phenyl)acetamide as a notable SARM1 inhibitor, which demonstrated significant efficacy in a mouse model of CIPN (Fig

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This positions GSH as an abundant intermediate carrier that forms a large, exchangeable Cu + pool, buffering copper ions between cellular uptake and delivery to high-affinity protein targets

These analytical procedures provide confirmation of compound identity, purity, traceability and batch consistency while ensuring every production batch meets Grail Formulas strict research quality standards

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PMID: 40398531